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NICE recommends semaglutide (TA875) and liraglutide (TA664) for specific patient groups with obesity, having reviewed comprehensive safety data including pancreatic outcomes

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In fact, as well detail in a later section, liraglutide in 2016 became the first GLP-1 agonist shown to reduce cardiovascular events in a dedicated outcomes trial (LEADER) an immensely important finding that added another dimension to its therapeutic profile

Early ultrastructural analysis indicated no sex differences in numerical density of dendritic spine or shaft synapses at postnatal day 5 (126), but a subsequent stereological analysis reported that the number of both types of synapses was greater in males at this same developmental time point and persisted throughout life